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The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

《农业科学与工程前沿（英文）》 2016年 第3卷 第2期   页码 147-152 doi: 10.15302/J-FASE-2016099

摘要： In cows, progesterone (P4) is essential for the maintenance of pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-related cytokines. However, investigation of the relationship between P4 and Th immunity in cattle remains incomplete. Therefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukins IL-1β, IL-4 and IL-6, in 15 pregnant and 11 non-pregnant cows 0, 14, 18, 21, and 28 d post artificial insemination. Pregnant cows had significantly higher plasma P4 levels and pregnant cows with higher P4 on 14 d tended to have higher P4 in the subsequent period of pregnancy. There was no difference in IL-4 and IL-6 expression between pregnant cows and non-pregnant cows, whereas plasma IL-1β was temporally upregulated on 21 d. The cytokines measured were not affected in either the high-P4 group (>11.1 ng·mL ) or the low-P4 group (<11.1 ng·mL ) in pregnant cows. A weak negative correlation between IL-1β and IL-6 was observed, but none of the cytokines was associated with a change in plasma P4. In conclusion, there was no clear relationship between P4 and Th immunity in maternal plasma in the pregnant cows, which differs from what occurs in humans and mice during early pregnancy.

关键词： dairy cow     progesterone     pregnancy     cytokine    

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Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

《医学前沿（英文）》 2009年 第3卷 第2期   页码 216-219 doi: 10.1007/s11684-009-0028-3

摘要： The purpose of this study was to investigate the expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion, and study the relationship of medical abortion through mifepristone and inducible nitric oxide synthase (iNOS) in early pregnancy. Expression of iNOS in trophoblasts and deciduas was detected by both hybridization and immunohistochemical assay in 40 patients (experimental group); the positive expression of iNOS was represented by number density (N/S) and positive unit (Pu) using computer color magic image analysis system (CMIAS). All results were compared with that obtained from vacuum aspiration. In the experimental group, N/S and Pu in trophoblasts were 0.120 ± 0.010 and 15.3 ± 2.6, respectively, while in the control group, they were 0.021 ± 0.003 and 3.1 ± 0.5, respectively, and there were significant differences between the two groups. By immunohistochemical assay, N/S and Pu were 0.090 ± 0.010, 10.24 ± 1.55 0.016 ± 0.002, 1.26 ± 0.33 in the trophoblasts of the two groups; there were also significant differences between the two groups. There were lower iNOS expressions in deciduas by in situ hybridization and immunohistochemical assay, and the difference between the two groups was not significant.It was concluded that mifepristone induced medical abortion through the expression of iNOS in trophoblasts but not in deciduas.

关键词： mifepristone     inducible nitric oxide synthase     early pregnancy     placental immunity    

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

《医学前沿（英文）》 2023年 第17卷 第3期   页码 549-561 doi: 10.1007/s11684-022-0965-7

摘要： Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

关键词： pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

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Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis

Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin

《医学前沿（英文）》 2019年 第13卷 第1期   页码 121-125 doi: 10.1007/s11684-018-0615-2

摘要： This retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomes and prognoses of patients with genital tuberculosis (GTB) who had received laparoscopy and/or hysteroscopy. This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatment. A total of 11 pregnancies (36.7%) in the ATT group and 19 pregnancies (63.3%) in the nonATT group were observed. Pregnancy rates significantly differed ( = 0.002) between the two groups. ATT may decrease the menstrual volume and pregnancy rates of patients who were diagnosed with GTB through laparoscopy and/or hysteroscopy. In addition, ATT did not improve the prognosis of patients with chronic GTB.

关键词： antitubercular treatment     pregnancy     prognosis     genital tuberculosis    

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Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 380-383 doi: 10.1007/s11684-015-0407-x

摘要：

Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal complications. A case of CS during the third trimester of pregnancy secondary to adrenocortical adenoma was reported. Literature review revealed the disadvantages of different treatments in this period. Besides the conservative treatment, surgery is recommended for CS during the third trimester of pregnancy secondary to adrenal adenoma, if an experienced surgeon is available.

关键词： Cushing’s syndrome     pregnancy     adrenocortical adenoma    

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继发性中晚期腹腔妊娠诊断和治疗 ——附一例病例报道

申颖,戴姝艳

《中国工程科学》 2015年 第17卷 第6期   页码 61-64

摘要：

目的：探讨继发性中晚期腹腔妊娠的诊断以及治疗方案。方法：回顾性地分析和总结我院收治的1例继发性中晚期腹腔妊娠的诊断及治疗方案。结果：该病例经磁共振成像（MRI）检查明确诊断，同时成功予以手术治疗。结论：继发性中晚期腹腔妊娠非常罕见，临床症状不典型，早期诊断较困难，MRI是一种有效的诊断方法，手术是最重要的治疗方式。

关键词： 腹腔妊娠     诊断     治疗     磁共振成像    

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women     bone mineral density     exercise     effects    

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RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 19-36 doi: 10.15302/J-FASE-2021411

摘要：

The importance of food security, especially in combating the problem of acute hunger, has been underscored as a key component of sustainable development. Considering the major challenge of rapidly increasing demands for both food security and safety, the management and control of major pests is urged to secure supplies of major agricultural products. However, owing to global climate change, biological invasion (e.g., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pest outbreaks are becoming more frequent and serious, making China, one of the world’s largest country in terms of agricultural production, one of the primary victims of crop yield loss and the largest pesticide consumer in the world. Nevertheless, the use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. This review summarizes the most fundamental information on pest monitoring and early warning in China by documenting the developmental history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related countries.

 

关键词： China / law / early warning system and national crop pest monitoring / pest management / regulation and sustainable agricultural development    

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Role of chemerin/CMKLR1 in the maintenance of early pregnancy

Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing

《医学前沿（英文）》 2018年 第12卷 第5期   页码 525-532 doi: 10.1007/s11684-017-0577-9

摘要：

Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed to explore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of early pregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnant women and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chain reaction analyses. CMKLR1 receptor antagonist (α-NETA) was then intrauterinely injected into normal pregnant mice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in decidua tissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortion was lower than in those who had experienced normal early pregnancy (P<0.01); conversely, CMKLR1 expression was higher in the former than in the latter (P<0.01). In a pregnant-mouse model, the embryo resorption rate of α-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P<0.001). Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the α-NETA-treated group (P<0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation.

关键词： chemerin     CMKLR1     early abortion    

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Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

《机械工程前沿（英文）》 2017年 第12卷 第3期   页码 357-366 doi: 10.1007/s11465-017-0423-4

摘要：

Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition (SVD)-based denoising may result in loss of useful information. A weak characteristic information extraction based on µ-SVD and local mean decomposition (LMD) is developed to address this problem. The basic principle of the method is as follows: Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and µ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.

关键词： wind turbine generator gearbox     µ-singular value decomposition     local mean decomposition     weak characteristic information extraction     early fault warning    

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Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

《医学前沿（英文）》 2018年 第12卷 第6期   页码 624-633 doi: 10.1007/s11684-018-0669-1

摘要：

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

关键词： diabetes     early-onset     diabetes complications    

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

《医学前沿（英文）》 2022年 第16卷 第2期   页码 157-175 doi: 10.1007/s11684-021-0884-z

摘要： Cancer imposes a severe threat to people’s health and lives, thus pressing a huge medical and economic burden on individuals and communities. Therefore, early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients. Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions, which reflects remarkable information regarding the cancer microenvironment, and plays an important role in the occurrence and evolution of cancer. Meanwhile, biosensors have gained great attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time readout, high sensitivity, and remarkable specificity, suggesting promising biomedical applications in the early diagnosis of cancer. In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated. Moreover, the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.

关键词： biosensor     exosome     cancer diagnosis    

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The early signal substances induced by heat stress in brains of mice

WANG Chunxu, WANG Hanxing

《医学前沿（英文）》 2008年 第2卷 第4期   页码 391-395 doi: 10.1007/s11684-008-0075-1

摘要： To study the effects of early signal substances induced by heat stress in brains of Kunming mice, six-month-old mice ( = 72) were pretreated with heat stress and subsequent ischemia/reperfusion by clipping of their bilateral cervical common arteries for 7 min. According to different treatments, animals were randomly divided into four groups: (1) normal control group; (2) heat stress pretreatment followed by ischemia and reperfusion group (HS/IR); (3) ischemia and reperfusion group (IR); (4) heat stress group (HS). Animals in the later three groups were subdivided into 3 subgroups (1 day, 4 days, 14 days), respectively. The changes in the expression of cAMP response element binding protein (CREB) and calcitonin gene-related peptide (CGRP) were detected by immunohistochemistry and computer image analysis methods. The results showed that compared with the normal group, the expressions of CREB in the hippocampal CA1 region increased significantly in the HS, HS/IR and IR groups ( < 0.05). Compared to the normal group, heat stress could result in CGRP excretion and redistribution in the cerebrum, with the highest level in the 4 d HS/IR group. Following heat stress, CGRP immunoreactivity was observed in varicose fibers and neuronal perikarya within the CA1 region. The results indicate that heat stress can induce CREB expression, which in turn stimulates CGRP secretion.

关键词： calcitonin gene-related     subsequent ischemia/reperfusion     computer     cerebrum     CGRP excretion    

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育龄妇女非意愿妊娠原因分析与对策研究

王代权,刘长艳,向琼,马代慈

《中国工程科学》 2014年 第16卷 第5期   页码 11-15

摘要：

采取整群抽样调查方法，对2011 年1 月—2013 年5 月在秭归县、夷陵区计划生育服务站因非意愿妊娠而实行人工终止妊娠对象，通过查阅病历资料和调查问卷，了解非意愿性妊娠原因及相关因素。1 360例非意愿妊娠中，未婚为21.62 %，已婚为78.38 %；人群分布在20～39 年龄段（73.82 %）；孕次分布主要在孕2～孕3 的对象为57.87 %；非意愿妊娠中避孕措施失败者为44.34 %，无措施者为55.66 %。避孕措施因素宫内节育器为10.51 %，避孕套为10.51 %，避孕药为8.24 %，外用为6.62 %，其他为8.46 %。存在侥幸心理和取出宫内节育器（IUD）后续措施没能跟进是无措施者导致非意愿妊娠的主要原因。避孕知识知晓率为98.90 %，对紧急避孕的知晓率仅为15.37 %，知道哺乳期需避孕者为18.38 %。医务人员、计生干部、宣传资料是已婚人群获取避孕知识的主要途径，农民及农民工对象获取免费服务高于城镇居民、国家工作人员、商业服务人员及外来流入人员。

关键词： 育龄妇女     非意愿妊娠     人工流产     影响因素    

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免费孕前优生健康检查对象潜在危险因素接触和妊娠结局分析

车焱,周公望,王彩琴,张焕玲,张建娥,闫立新,陆珍,陆梅,沈洁,朱昊平

《中国工程科学》 2014年 第16卷 第5期   页码 56-59

摘要：

分析并报告上海市静安区免费孕前优生健康检查后待孕夫妇不良妊娠结局潜在影响因素接触情况以及妊娠率和妊娠结局，为免费孕前健康检查政府实施项目效果的评估提供基础数据。对2011 年8 月—2012 年11 月在静安区参加免费孕前优生健康检查的所有对象在其检查结束后的3 个月、6 个月、12 个月进行随访，重点关注不良妊娠结局潜在危险因素接触情况以及妊娠时间和妊娠结局。统计方法为χ2检验、寿命表、Logistic 回归分析。在目标时段内共有1 480 对夫妇参加了免费孕前优生健康检查，其中1 249 对服务对象接受了随访，随访率为84.4 %。截至2013 年4 月，48.7 %的随访对象已经受孕，孕前检查后3 个月调查累积妊娠率为23.9 %，6 个月调查累积妊娠率为45.0 %。365 人完成妊娠结局的随访，结果显示，早产率为3.0 %，低出生体重率为4.3 %，巨大儿发生率为3.3 %。自然流产率为6.3 %。另外，发现出生缺陷1 人，占妊娠妇女数的0.16 %，占有妊娠结局妇女数的0.27 %。烟酒等不良生活习惯丈夫的比例（18 %～20 %）高于妻子（1 %～3 %），77 %的丈夫和妻子接受潜在电磁辐射的时间超过8 h。9 %的夫妇自述生活和工作中接触重金属以及农药、化肥等潜在致畸物。超过10 %的妻子在怀孕以后接触了潜在致畸物。初步分析未发现上述因素与不良妊娠结局的关系。静安区孕前健康检查后半年内妇女妊娠率不到50 %，有必要在上海乃至全国开展免费孕前健康检查的成本效益评估。

关键词： 孕前优生健康检查     妊娠率     累积妊娠率     不良妊娠结局     危险因素    

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标题 作者 时间 类型 操作

The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

期刊论文

Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

期刊论文

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

期刊论文

Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis

Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin

期刊论文

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

null

期刊论文

继发性中晚期腹腔妊娠诊断和治疗 ——附一例病例报道

申颖,戴姝艳

期刊论文

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

期刊论文

RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

期刊论文

Role of chemerin/CMKLR1 in the maintenance of early pregnancy

Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing

期刊论文

Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

期刊论文

Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

期刊论文

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

期刊论文

The early signal substances induced by heat stress in brains of mice

WANG Chunxu, WANG Hanxing

期刊论文

育龄妇女非意愿妊娠原因分析与对策研究

王代权,刘长艳,向琼,马代慈

期刊论文

免费孕前优生健康检查对象潜在危险因素接触和妊娠结局分析

车焱,周公望,王彩琴,张焕玲,张建娥,闫立新,陆珍,陆梅,沈洁,朱昊平

期刊论文